Preview Mode Links will not work in preview mode

The Aliquot Preview

Nov 30, 2021

Protein is essential for maintaining muscle mass as we age. Modulating protein intake via dietary intake or fasting can have variable effects on aging and muscle growth. Whereas fasting turns off multiple pathways associated with aging, such as mTOR, IGF-1, growth hormone, and others, eating for optimal fitness activates these important processes. 

In this aliquot, we discuss:
  • (00:00) Introduction
  • (02:57) Growth-longevity trade-off (Mike Maser discussion)
  • (11:45) Role of IGF-1 in the aging process (Valter Longo discussion)
  • (12:55) mTOR and the IGF-1 regulation by amino acids (Peter Attia discussion)
  • (15:55) Anti-cancer effect of glutamine restriction outweigh the negative effect of glutamine deprivation on the gut and liver (Dominic D’Agostino discussion)
  • (22:45) The possibility of using selective nutrient restriction as an autophagy-inducer (Guido Kroemer discussion
  • (26:23) The IGF-1 Trade-Off: Performance vs. Longevity (Rhonda Patrick discussion)

Get more Aliquots! Become a FMF Premium member and get full access to our members-only podcast, The Aliquot, plus live Q&As with Rhonda, biweekly Science Digest emails, and more.

Learn more and sign up at: