May 21, 2026
With Mirvat Alasnag, King Fahd Armed Forces Hospital, Jeddah - Saudi Arabia and Thomas Kümler, Steno Diabetes Center, Copenhagen, Herlev - Denmark
In this podcast, Mirvat Alasnag joins Thomas Kumler to discuss
TAVI in women.
References:
1. Tchetche D, Pibarot P, Bax JJ, Bonaros N, Windecker S,
Dumonteil N, Nietlispach F, Messika-Zeitoun D, Pocock SJ,
Berthoumieu P, Swaans MJ, Timmers L, Rudolph TK, Bleiziffer S,
Leroux L, Modine T, van der Kley F, Auffret V, Tomasi J, Stastny L,
Hengstenberg C, Andreas M, Leclercq F, Gandet T, Mascherbauer J,
Trescher K, Prendergast B, Vasa-Nicotera M, Chieffo A, Mares J,
Wesselink W, Rakova R, Kurucova J, Bramlage P, Eltchaninoff H.
Transcatheter vs. surgical aortic valve replacement in women: the
RHEIA trial. Eur Heart J. 2025;46:2079–88.
doi:10.1093/eurheartj/ehaf133. https://academic.oup.com/eurheartj/article/46/22/2079/8103699
2. Eltchaninoff H, Bonaros N, Prendergast B, Nietlispach F,
Vasa-Nicotera M, Chieffo A, Pibarot P, Bramlage P, Sykorova L,
Kurucova J, Bax JJ, Windecker S, Dumonteil N, Tchetche D. Rationale
and design of a prospective, randomized, controlled, multicenter
study to evaluate the safety and efficacy of transcatheter heart
valve replacement in female patients with severe symptomatic aortic
stenosis requiring aortic valve intervention (Randomized researcH
in womEn all comers wIth Aortic stenosis [RHEIA] trial). Am Heart
J. 2020;228:27–35. https://www.sciencedirect.com/science/article/pii/S0002870320301964
3. Silva I, Alperi A, Hecht S, Zanuttini A, Théron A, Giuliani
C, Camacho B, Dahou A, Mares J, Bax J, Bonaros N, Windecker S,
Messika-Zeitoun D, Wesselink W, Rakova R, Bramlage P, Tchétché D,
Eltchaninoff H, Pibarot P; RHEIA Trial Investigators.
Echocardiographic results of transcatheter versus surgical aortic
valve replacement in women with severe aortic stenosis: the RHEIA
trial. J Am Heart Assoc. 2025.
doi:10.1161/JAHA.125.047196. https://www.ahajournals.org/doi/10.1161/JAHA.125.047196
4. Eltchaninoff H, Windecker S, Mack MJ, Pibarot P, Thourani
VH, Bax JJ, Cohen DJ, Bonaros N, Makkar R, Bleiziffer S, Szeto WY,
Berthoumieu P, Hahn RT, Hovorka T, Mareš J, Taylor J, Tchetche D,
Leon MB. Aortic Valve Replacement in Women: A Pooled Analysis of
the RHEIA and PARTNER 3 Trials. JACC Cardiovasc Interv.
2025;18:1540-53. https://www.jacc.org/doi/10.1016/j.jcin.2025.03.036
5. Herrmann HC, Mehran R, Blackman DJ, Bailey S, Möllmann H,
Abdel-Wahab M, Ben Ali W, Mahoney PD, Ruge H, Wood DA, Bleiziffer
S, Ramlawi B, Gada H, Petronio AS, Resor CD, Merhi W, Garcia Del
Blanco B, Attizzani GF, Batchelor WB, Gillam LD, Guerrero M, Rogers
T, Rovin JD, Szerlip M, Whisenant B, Deeb GM, Grubb KJ, Padang R,
Fan MT, Althouse AD, Tchétché D; SMART Trial Investigators.
Self-expanding or balloon-expandable TAVR in patients with a small
aortic annulus (SMART trial). N Engl J Med.
2024;390:1959–71. https://www.nejm.org/doi/10.1056/NEJMoa2312573
6. Herrmann HC, Tchetche D, Mehran R, et al. SMART trial
2-year outcomes: continued superior valve performance for the
self-expanding TAVR system in small annulus patients. Presented at
CRT 2025: 8-11 March 2025, Washington, DC, USA
7. Praz F, Borger MA, Lanz J, Marin-Cuartas M, Abreu A, Adamo
M, Ajmone Marsan N, Barili F, Bonaros N, Cosyns B, De Paulis R,
Gamra H, Jahangiri M, Jeppsson A, Klautz RJM, Mores B, Pérez-David
E, Pöss J, Prendergast BD, Rocca B, Rossello X, Suzuki M, Thiele H,
Tribouilloy CM, Wojakowski W; ESC/EACTS Scientific Document Group.
2025 ESC/EACTS guidelines for the management of valvular heart
disease. Eur Heart J. 2025;46:4635–736. https://academic.oup.com/eurheartj/article/46/44/4635/8234488
8. Mack MJ, Leon MB, Thourani VH, Makkar R, Kodali SK, Russo
M, Kapadia SR, Malaisrie SC, Cohen DJ, Pibarot P, Leipsic J, Hahn
RT, Blanke P, Williams MR, McCabe JM, Brown DL, Babaliaros V,
Goldman S, Szeto WY, Genereux P, Pershad A, Pocock SJ, Alu MC, Webb
JG, Smith CR; PARTNER 3 Investigators. Transcatheter aortic-valve
replacement with a balloon-expandable valve in low-risk patients
(PARTNER 3). N Engl J Med. 2019;380:1695–705. https://www.nejm.org/doi/10.1056/NEJMoa1814052
9. Kodali S, Williams MR, Doshi D, Hahn RT, Humphries KH,
Nkomo VT, Cohen DJ, Douglas PS, Mack M, Xu K, Svensson L, Thourani
VH, Tuzcu EM, Weissman NJ, Leon M, Kirtane AJ. Sex-specific
differences at presentation and outcomes among patients undergoing
transcatheter aortic valve replacement: a cohort study. Ann Intern
Med. 2016;164:377–84. https://www.acpjournals.org/doi/10.7326/M15-0121
10. Chieffo A, Petronio AS, Mehilli J, Chandrasekhar J,
Sartori S, Lefèvre T, Presbitero P, Capranzano P, Tchetche D,
Iadanza A, Sardella G, Van Mieghem NM, Meliga E, Dumonteil N,
Fraccaro C, Trabattoni D, Mikhail G, Sharma S, Ferrer MC, Naber C,
Kievit P, Baber U, Snyder C, Sharma M, Morice MC, Mehran R;
WIN-TAVI Investigators. 1-Year Clinical Outcomes in Women After
Transcatheter Aortic Valve Replacement: Results From the First
WIN-TAVI Registry. JACC Cardiovasc Interv.
2018;11:1–12. https://www.jacc.org/doi/10.1016/j.jcin.2017.09.034
11. Tateishi K, Hmoud H, De Gregorio I, Hastings R, De
Gregorio J. The impact of gender on outcomes of transcatheter
aortic valve implantation between self-expanding valve and
balloon-expandable valve. Cardiovasc Revasc Med.
2024;63:38–42. https://www.sciencedirect.com/science/article/abs/pii/S1553838924000034
12. Iribarren AC, AlBadri A, Wei J, Nelson MD, Li D, Makkar R,
Merz CNB. Sex differences in aortic stenosis: identification of
knowledge gaps for sex-specific personalized medicine. Am Heart J
Plus. 2022;21:100197. https://pmc.ncbi.nlm.nih.gov/articles/PMC9629620/
13. Springhetti P, Abdoun K, Clavel M-A. Sex differences in
aortic stenosis: from the pathophysiology to the intervention,
current challenges, and future perspectives. J Clin Med.
2024;13:4237. https://www.mdpi.com/2077-0383/13/14/4237
14. Tastet L, Kwiecinski J, Pibarot P, Capoulade R, Everett
RJ, Newby DE, Shen M, Guzzetti E, Arsenault M, Bédard É, Larose É,
Beaudoin J, Dweck M, Clavel MA. Sex-related differences in the
extent of myocardial fibrosis in patients with aortic valve
stenosis. JACC Cardiovasc Imaging. 2020;13:699–711. https://www.jacc.org/doi/10.1016/j.jcmg.2019.06.014
15. Treibel TA, Kozor R, Schofield R, Benedetti G, Fontana M,
Bhuva AN, Sheikh A, López B, González A, Manisty C, Lloyd G,
Kellman P, Díez J, Moon JC. Reverse myocardial remodeling following
valve replacement in patients with aortic stenosis. J Am Coll
Cardiol. 2018;71:860–71. https://www.jacc.org/doi/10.1016/j.jacc.2017.12.035
16. Stangl V, Baldenhofer G, Laule M, Baumann G, Stangl K.
Influence of sex on outcome following transcatheter aortic valve
implantation (TAVI): systematic review and meta-analysis. J Interv
Cardiol. 2014;27:531–9. https://onlinelibrary.wiley.com/doi/epdf/10.1111/joic.12150
17. Tribouilloy C, Bohbot Y, Rusinaru D, Belkhir K, Diouf M,
Altes A, Delpierre Q, Serbout S, Kubala M, Levy F, Maréchaux S,
Enriquez Sarano M. Excess mortality and undertreatment of women
with severe aortic stenosis. J Am Heart Assoc.
2021;10:e018816.
18. Bienjonetti-Boudreau D, Fleury M-A, Voisine M, Paquin A,
Chouinard I, Tailleur M, et al. Impact of sex on the management and
outcome of aortic stenosis patients. Eur Heart J.
2021;42(27):2683–2691. https://www.ahajournals.org/doi/10.1161/JAHA.120.018816