GLP-1s and Muscle Loss - What a Nutrition PhD Wants You To Know

Apr 20, 2026

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Millions of people are taking GLP-1 medications like Ozempic and Mounjaro, and the weight loss results speak for themselves.

But there's a critical conversation most people aren't having: what's actually happening to your muscle while the scale goes down.

In this episode, I break down exactly what the research shows about lean mass loss on semaglutide and tirzepatide, why it matters far more than most people realize, and what you need to do right now to protect your results long-term. 

What you'll learn:

• How GLP-1 medications actually work in your body What the STEP and SURMOUNT trials reveal about muscle loss
• Why losing muscle slows your metabolism and sets you up for weight regain
• The #1 most evidence-based strategy to preserve muscle during weight loss
• How much protein you actually need, and why GLP-1s make this harder
• Why slow weight loss beats fast weight loss, even on medication
• The real reason 66% of people regain weight within a year of stopping GLP-1s
• GLP-1s are a legitimate and powerful tool. But without the right plan in place, you risk losing the wrong kind of weight and ending up worse off than when you started.