Jun 21, 2025
Computational neuroscientists rely on simplification when they make their models. But what is the right level of simplification?
When should we, for example, use a biophysically detailed model and when a simplified abstract model when modelling neural dynamics? What are the problems of simplifying too much, or...
May 24, 2025
A future computational neuroscience project could be to model not only the signal processing properties of neurons, but also all processes that keep a neuron alive for, say, a 100-year life span.
In 2012 the group of the guest published the first such whole-cell model for a very simple bacterium (M. genitalia). In 2020...
Apr 26, 2025
Numerous neuron models have been made, but most of them are "single-purpose" in that they are made to address a single scientific question. In contrast, multipurpose neuron models are made to be used to address many scientific questions.
In 2011, the guest published a multipurpose rodent pyramidal-cell model which has...
Mar 29, 2025
With modern electrical and optical measurement techniques, we can now measure neural activity in hundreds or thousands of neurons simultaneously. This allows for the investigation of population codes, that is, of how groups of neurons together encode information.
In 2019 today’s guest published a seminal paper with...
Mar 1, 2025
The observed variety of dendritic structures in the brains is striking. Why are they so different, and what determine the branching patterns?
Following the dictum “if you understand it, you can build it”, the lab of the guest builds dendritic structures in a computer and explore the underlying principles.
Two...